Field plot experiment was used to study the effect of alfalfa and maize rotation on improving fertilizer cultivation of moderate soda-salinic soil in the western of Jilin Province. The results indicated that the soil physical, biological and chemical properties were significantly improved after the grain-grass rotation in moderately alkaline soil, soil bulk density showed a gradual decline trend and porosity increased gradually. The changes of soil chemical properties showed that the pH value, total alkalinity and exchangeable sodium decreased significantly, the content of exchangeable calcium increased. The activities of soil urease and phosphatase were significantly increased, and the maize yield showed a steady increase trend. So grain-grass rotation had better comprehensive fertilizer improvement effect on moderately alkaline soil, which was suitable for the improvement of saline-alkali soil in the western of Jilin Province.