In order to explore the optimal planting density and fertilizer scheme of‘Jihua 1’peanut, four factors and five levels regression rotation design was adopted in the experiment. Optimized mathematical model of each factor and yield index was established, and high-yield cultivation and optimization scheme was determined. The results showed that the influence degree of each factor on Jihua1 yield was density> N > P > K. The optimal schemes of high-yield of ‘Jihua 1’(higher than 3 300.00 kg/ha) was: the density was 132.92 k-137.67 k points/ha, the nitrogen application rate was 217.7-241.1 kg/ha, the phosphate application rate was 179.52-206.36 kg/ha, the potassium application rate was 191.68-210.68 kg/ha.