植物代谢工程研究进展

Progress in Studies on Genetic Engineering of Secondary Metabolites in Plant

摘要:

植物代谢工程是采用分子生物学、生物化学、功能基因组学、蛋白组学和代谢组学方法阐明植物复杂的代谢途径和代谢网络的分子机理,通过遗传工程技术在分子水平上调控代谢途径,以提高目标代谢物产量或降低有害代谢物的积累。本文综述了植物代谢工程,包括次生代谢关键酶基因工程、转录因子或调节基因的基因工程等方面的研究进展,以及系统生物学在植物代谢工程研究方面的应用。

Abstract:

Plant Metabolic engineering is the practice of optimizing genetic and regulatory processes within cells to enhance the production of known target metabolites or to reduce the accumulation of harmful metabolites,by combining the molecular biology,biochemistry,functional genomics,proteomics and metabolomics approach to clarify the complexity of plant metabolic pathways and molecular mechanism of metabolic networks.In this paper,the recent advances in plant metabolic engineering,including genetic engineering of key enzymes for secondary metabolism,transcription factors or regulate genes,and the applications of systematic biology to plant metabolic engineering were reviewed.